Posts By :

NurseJanna

CBD for Anxiety hills and trees

CBD For Anxiety

CBD For Anxiety 1900 800 NurseJanna

CBD For Anxiety


May 5, 2020

CBD for Anxiety hills and trees
DOES THE THOUGHT OF CBD FOR ANXIETY MAKE YOU MORE ANXIOUS? HERE’S WHY IT SHOULDN’T.

Over 40 million adults in the US have an anxiety disorder, with more women than men being affected. Anxiety disorders can include generalized anxiety disorder panic disorder, obsessive-compulsive disorder, social anxiety disorder, phobias, and post-traumatic stress disorder (1).

Research has shown CBD helps anxiety

It’s possible to reduce anxiety with pharmaceuticals but for those who have walked away from pharmaceuticals because of their limited effectiveness, side effects, or cost, CBD provides a good option. “Preclinical studies have shown that the non-psychotropic phytocannabinoid cannabidiol (CBD) and the endocannabinoid anandamide (part of CBD) have acute anti-anxiety effects and also regulate learned fear by dampening its expression, enhancing its extinction and disrupting its reconsolidation.” (2)

How CBD affects your endocannabinoid system

The endocannabinoid system (ECS) is a communication system in the body that regulates virtually every function in the body including immune response, mood, appetite and metabolism, communication between cells, memory, etc. Amazingly, this system was only discovered in the 90s.

Research shows that CBD interacts with several endocannabinoid receptors in your body known to regulate fear and anxiety-related behaviors, including the serotonin 5-HT1A receptor, and the CB1 and CB2 receptors which are found throughout our brain and body, in our endocannabinoid system (4). CBD is able to reduce anxiety because of its ability to breakdown enzymes (FAAH and MAGL) in the synaptic gaps directly inhibiting the reuptake of our body’s natural endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide, also known as the “bliss molecule”. Without CBD, in the synaptic gap, the FAAH enzyme can degrade anandamide and the MAGL enzyme can degrade 2-AG at a faster rate (2 & 5). With CBD use, this allows anandamide and 2-AG to hang out longer in our synaptic gaps, helping us to maintain an elevated mood, reducing our anxiety.

Since everyone’s endocannabinoid system has different concentrations of anandamide and 2-AG–our naturally occurring endocannabinoids–too little CBD can be ineffective, and too much can increase anxious feelings (2). In addition, different strains of CBD and their plant profile, affect us all differently. CBD that works for your friend’s anxiety, may not work for you.

There are a number of variables when working with CBD to improve health, and documenting the brand, strain, delivery method, dose, are all important components to assessing what works best to reduce your anxiety. It is always important to start with a low dose of CBD, noting any decrease or increase in anxiety and adjust the dose accordingly.

As always, consult with your healthcare provider when using CBD especially if you are taking other supplements or prescriptions drugs as there could be contraindications. CBD or hemp is not a “miracle drug”, it is a plant that has health benefits and as more clinical trials take place we will continue to increase our understanding of this plant and its application to support health and well-being.

Blessings,
Janna Champagne, RN

References
1. Bandelow, B., & Michaelis, S., (2015). Epidemiology of anxiety disorders in the 21st century. Dialogues in Clinical Neuroscience, 17(3), 327-335. Retrieved from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610617/

2. Papagianni, E., & Stevenson, C., (2019). Cannabinoid regulation of fear and anxiety: An update. Current Psychiatry Reports, 21(6): 38. https://doi.org/10.1007/s11920-019-1026-z

3. Blessing, E., Steenkamp, M., Manzanares, J., & Marmar, C., (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836. Retrieved from https://dx.doi.org/10.1007/s13311-015-0387-1

4. Scherma, M., Masia, P., Satta, V., Fratta, W., Fadda, P., & Gianluigi, T, (2018). Brain activity of anandamide: A rewarding bliss? Acts Pharmacolgica Sinica, 40, 309-323. https://doi.org/10.1038/s41401-018-0075-x

5. Mackie, K., (2008). Cannabinoid receptors: Where they are and what they do. Journal of Neuroendocrinology, 20(1). https://doi.org/10.1111/j.1365-2826.2008.01671.x

CBD for Immunity landscape with green fields

CBD For Immunity

CBD For Immunity 1900 800 NurseJanna

CBD For Immunity


May 4, 2020

CBD for Immunity landscape with green fields
CBD AND CBG ARE A POWERFUL COMBO FOR IMMUNE SUPPORT.

Today, more than ever, people are really worried about keeping their immune system healthy. That’s why sales of natural, immune remedies have surged. Sales in March for Vitamin C were up 146%, zinc up 255%, and elderberry up 415% (source: IRI). With everyone turning to supplements to stay healthy, many supplements are out of stock.

The endocannabinoid system supports your immunity

The amazing thing about our endocannabinoid system (ECS) is that when it is in balance, in homeostasis, it supports our immune system. Our ECS has two receptors, (that’s what we know now but that could change as we learn more), CB1 and CB2. CB1 receptors are widely distributed in the central nervous system, and peripheral organs and tissues, and there is some speculation that CB1 receptors are also on immune cells. CB2 receptors are located in immune cells, the spleen, and the thymus. Our endocannabinoids, the cannabinoids our body naturally makes, increase with the use of cannabidiol (CBD) and cannabigerol (CBG), and as a result, supports our immune system and decreases inflammation (1).

Never heard of CBG. You’re not alone.

CBG has flown under the consumer radar probably due to being overshadowed by CBD and THC (tetrahydrocannabinol). CBG requires more logistical planning because it potentially involves harvesting cannabis crops earlier when the concentration of CBG is higher. CBG is one of the most expensive cannabinoids to produce and has been called the “Rolls Royce of cannabinoids.” “It takes thousands of pounds of biomass to create small amounts of CBG isolate,” James Rowland, CEO of the CBG brand Steve’s Goods, told Forbes.

CBD and CBG are non-psychoactive, have anti-inflammatory and antioxidant properties, and neuroprotective effects including the recovery and regeneration of the nervous system (2, 3). CBD and CBG have been shown to cause cell death in specific cancer cells, inhibit cell growth of some tumor cells (4, 5) via the immune response, which is activated by the endocannabinoid system (ECS). “There is some evidence suggesting the involvement of the ECS in the control and elimination of infectious agents such as bacteria, viruses, and some protozoa.” (4,6)

How to maintain a healthy immune system

Maintaining a healthy immune system also includes reducing our stress, eating healthy, having a good social network, reducing or eliminating alcohol intake, getting enough sleep and exercise, and of course washing your hands. These are all solid steps to boosting immune health, not only for ourselves but for those around us. For extra immune support, CBD and CBG are a good option.

As always, consult with your healthcare provider when using CDB or CBG especially if you are taking other supplements or prescriptions drugs as there may be contraindications. CBD, CBG or hemp is not a “miracle drug”, it is a plant that has health benefits and as more clinical trials take place, we will grow our understanding of this plant and its application to support health and well-being.

Blessings,
Janna Champagne, RN

References
1. Turcotte, C., Blanchet, M., Laviolette, M., & Flamand, N., (2016). The CB2 receptor and its role as a regulator of inflammation. Cellular and Molecular Life Sciences, 73, 4449-4470. Retrieved from https://link.springer.com/article/10.1007%2Fs00018-016-2300-4

2. Gugliandolo, A., Bramanti, P., Mazzon, E., Pollastro, F., & Grassi, G., (2018). In vitro model of neuroinflammation: Efficacy of cannabigerol a non-psychoactive cannabinoid. International Journal of Molecular Sciences, 19(7). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073490/

3. Rodrigues, R., Lourenco, D., Paulo, S., Mateus, J., Ferreira, M., Mouro, F., Moreira, J., Ribeiro, F., Sebastiao, A., & Xapelli, S., (2019). Cannabinoid actions on neural stem cells: Implication for pathophysiology. International Journal of Molecules Sciences, 24(7), 1350. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480122/

4. Hernandez/-Cervantes, R., Mendex-Diaz, M., Prospero-Garcia, O., & Morales-Montor, J., (2017). Immunoregulatory role of cannabinoids during infections disease. Neuroimmunomodulation, 24, 183-199. Retrieved from https://ww.karger.com/Article/Pdf/481824

5. Massi, P., Solinas, M., Cinquinnna, V., & Parolaro, D., (2014). Cannabidiol as a potential anticancer drug. British Journal of Clinical Pharmacology, 75(2), 303-312. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579246/

6. Reiss, C., (2010). Cannabinoids and viral infections. Pharmaceuticals 3(6), 1873-1886. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903762/

landscape with green hills

CBD For Sleep

CBD For Sleep 1900 800 NurseJanna

CBD For Sleep


May 3, 2020

landscape with green hills
IF YOU’VE GIVEN UP ON BEING ABLE TO GET A GOOD NIGHT’S SLEEP, WE’VE GOT GOOD NEWS.

Insomnia affects 30 percent of the US population and is more prevalent in women than men. Insomnia is associated with difficulty falling asleep, difficulty maintaining sleep throughout the night, or a combination of both (1).

If you’re tired of relying on over-the-counter medicine or pharmaceuticals to fall asleep, it might be time to look for a more natural, holistic solution that works with your system, instead of against it. Insomnia not only saps your energy, it compromises your immune system, negatively affects your hormones and is linked to several serious health conditions.(1 & 2)

Why combine CBD with CBN?

The combination of CBD and CBN is gaining traction for those who experience insomnia. CBD in higher doses has a sedative, relaxing effect (3), and small amounts of CBN has been found in research to prolong sleep (4). It’s important to use full spectrum CBD, derived from the whole plant to create the entourage effect. The entourage effect is when all the compounds in the plant, once considered inactive, help boost the overall effectiveness.

The endocannabinoid system may play a role in regulating the sleep cycle (5), and more specifically the circadian rhythm, however this is still speculative. What we do know is that together these two amazing cannabinoids, CBN and CBD have a collective effect of relieving anxiety, reducing-inflammation, being neuroprotective and alleviating pain (6), all qualities that support good sleep.

Tips for finding what works for you

When I work with clients who have insomnia, I ask them to keep a sleep log to record the time they fell asleep (roughly), how long they slept, the actual time or times they woke up, and any consistent thoughts, positions and patterns to their sleep. I also encourage them to write a quick note about their dreams to give them insight into what might be contributing to insomnia.

Since there are a number of variables when working with CBD, CBN and terpenes to improve health, it is a good practice to document the brand, strain, delivery method, dose, as all of these variables are all important to assessing what works best to reduce insomnia. It is always important to start with a low dose of CBD and CBN and adjust the dose according to need.

At the end of the day, when your mind and body need to rest, and your endocannabinoid system needs some extra support, trying CBD and CBN may provide a restful night sleep for you.

Consult with your healthcare provider when using CBD and CBN especially if you are taking other supplements or prescriptions drugs as there may be contraindications. CBD, CBN or hemp is not a “miracle drug”, it is a plant that has health benefits and as more clinical trials take place we increase our understanding of this plant and its ability to improve health and well-being.

Blessings,
Janna Champagne, RN

References
1. The American Academy of Sleep Medicine, (2008). Insomnia, white paper. Retrieved from https://aasm.org/resources/factsheets/insomnia.pdf

2. Mallampalli, M. & Carter, C., (2014). Exploring sex and gender differences in sleep health: A society for women’s health research report. Journal of Women’s Health, 23(7), 553-562. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089020/

3. Zhornitsky, S., & Potvin, S., (2012). Cannabidiol in humans-The quest for therapeutic targets. Pharmaceuticals5, 529-552. https://doi.org/10.3390/ph5050529

4. Yoshida, H., Usami, N., Ohishi, Y., Watanabe, K., Yamamoto, I., & Yoshimura, H., (1995). Chemical and Pharmaceutical Bulletin, 43(2), 335-337. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/7728937

5. Tringale, R., & Jensen, C., (2011). Cannabis and insomnia. O’Shaughnessy’s-Society of Cannabis Clinicians, Autumn 2011. Retrieved from https://www.beyondthc.com/wp-content/uploads/2014/04/Tringale-Jensen-20111.pdf

6. Murillo-Rodriguez, E., Sarro-Ramirez, A., Sanchez, D., Mijangos-Moreno, S., Tejeda-Padron, A., Poot-Ake, A., Guzman, K., Pacheco-Pantoja, E., & Arias-Carrion, O., (2014). Current Neuropharmacology, 12(3), 269-272. Potential effects of cannabidiol as a wake-promoting agent. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023456/